The Kosmoplex Theory Project is centered on the exploration of Kosmoplex Theory and provides resources, preprints, code repositories, and visualizations related to this work. Kosmoplex Theory (KT) is a constraint-based mathematical framework deriving physical constants and structures from seven axioms with no free parameters. The approach is mathematical first: structures are derived from axioms and rigidity theorems rather than fitted to data. Physical interpretations and testable predictions are introduced only after the mathematical core is fixed. This site serves as a stable reference point for the project and its ongoing development. Site visitors are encouraged to download articles from a wide range of topics including medicine, mathematics, physics, and metaphysics.
Kosmoplex — from the Greek κόσμος (kosmos), meaning "order" or "universe," and the Latin plexus, from plectere, "to weave" or "braid" — names precisely what the theory describes: the ordered weaving of reality from discrete algebraic threads through the loom of the Fano plane and Pascal's simplex, a cosmos not created but woven.
Faculty Email: macedoni (the AT symbol) umich.edu
Kosmoplex Theory (KT) The ordered weaving of reality from discrete algebraic threads
Dr. Macedonia is a maternal-fetal medicine physician and genetics expert, and adjunct faculty at the University of Michigan College of Pharmacy. A retired Army Colonel, he served as a DARPA program manager, NIH researcher, and senior government scientist — a career spanning the intersection of medicine, computer science, defense technology, and fundamental research.
An active explorer (Fellow, The Explorers Club '96), Dr. Macedonia has dove the wreck of the Titanic in the Mir submersible, conducted telemedicine research on Everest with the E3 Expeditions, and worked in environments from the Amazon jungle to high-altitude desert. He is recognized as an expert in expedition medicine across Earth's most demanding terrain.
Dr. Macedonia developed Kosmoplex Theory as part of a larger pursuit of what he considers the single greatest challenge in science: how does life arise? How does information pack and unpack and, in between, become life? This question unifies his work as a physician who delivers life into the world every day, an information theorist, and a government scientist — and was the foundation of his most prominent named program at DARPA, Biochronicity. Kosmoplex Theory is where that pursuit led: a mathematical framework deriving the fundamental constants of physics from first principles with zero free parameters, suggesting that the boundary between living and non-living is not a boundary at all but a threshold of computational complexity in the same discrete geometric substrate that generates the constants of nature.
Faculty Email: macedoni AT umich.edu