C. Macedonia, "The Computational Kosmoplex: A Principia for Engineers in the Age of AI," in Computer, vol. 59, no. 3, pp. 70-83, March 2026, doi: 10.1109/MC.2025.3590236.

The Kosmoplex Theory Project is centered on the exploration of Kosmoplex Theory, and provides resources, preprints, code repositories, and visualizations related to this work. Kosmoplex Theory (KT) is a constraint-based mathematical framework deriving physical constants and structures from seven axioms with no free parameters. The approach is mathematical first: structures are derived from axioms and rigidity theorems rather than fitted to data. Physical interpretations and testable predictions are introduced only after the mathematical core is fixed. This site serves as a stable reference point for the project and its ongoing development.
Kosmoplex — from the Greek κόσμος (kosmos), meaning "order" or "universe," and the Latin plexus, from plectere, "to weave" or "braid" — names precisely what the theory describes: the ordered weaving of reality from discrete algebraic threads through the loom of the Fano plane and Pascal's simplex, a cosmos not created but woven.
Kosmoplex Theory (KT) The ordered weaving of reality from discrete algebraic threads
Dr. Macedonia is a maternal-fetal medicine physician and genetics expert, and adjunct faculty at the University of Michigan College of Pharmacy. A retired Army Colonel, he served as a DARPA program manager, NIH researcher, and senior government scientist — a career spanning the intersection of medicine, defense technology, and fundamental research.
An active explorer (Fellow, The Explorers Club '96), Dr. Macedonia has dove the wreck of the Titanic in the Mir submersible, conducted telemedicine research on Everest with the E3 Expeditions, and worked in environments from the Amazon jungle to high-altitude desert. He is recognized as an expert in expedition medicine across Earth's most demanding terrain.
Dr. Macedonia developed Kosmoplex Theory as part of a larger pursuit of what he considers the single greatest challenge in science: how does life arise? How does information pack and unpack and, in between, become life? This question unifies his work as a physician who delivers life into the world every day, an information theorist, and a government scientist — and was the foundation of his most prominent named program at DARPA, Biochronicity. Kosmoplex Theory is where that pursuit led: a mathematical framework deriving the fundamental constants of physics from first principles with zero free parameters, suggesting that the boundary between living and non-living is not a boundary at all but a threshold of computational complexity in the same discrete geometric substrate that generates the constants of nature.
Faculty Email: macedoni AT umich.edu
Zenodo (Principia Kosmoplex): DOI: 10.5281/zenodo.17861153 — citable preprint archive
The Codex Kosmoplex on Amazon:
Macedonia, C. (2026). The Fano–Pascal Spectral Theorem: Eigenvectors, Eigenvalues, and the Two Channels of Physical Reality. Zenodo. https://doi.org/10.5281/zenodo.18651280
Macedonia, C. (2026). The Critical Angle of Projection: A Geometric Answer to Hilbert's Eighth Question. Zenodo. https://doi.org/10.5281/zenodo.18651049
Macedonia, C. (2026). Gauge Theory as Octonionic Projection: The Geometry of the 168 Monads. Zenodo. https://doi.org/10.5281/zenodo.18650503
Macedonia, C. (2026). Supplement and Refinements to the Principia Kosmoplex Version 1.1 (Version 1). Zenodo. https://doi.org/10.5281/zenodo.18650087
Macedonia, C. (2026). Spinor Trigonometry and Exacalculus: Mathematical Tools for Discrete Systems Exhibiting Double-Cover Geometry. Zenodo. https://doi.org/10.5281/zenodo.18652970
Macedonia, C. (2026). Loco-genesis and the Bell Constraint: How Derived Locality Reopens the Question of Structure Beneath Quantum Mechanics (Version 1). Zenodo. https://doi.org/10.5281/zenodo.18650200
Macedonia, C. R. (2026). The Dynamic Zeros Under Closure: Irreducible Core of a Discrete Physical Computational Framework. Preprints. https://doi.org/10.20944/preprints202602.1783.v1
Macedonia, C. (2026). The Computational Lagrangian: How an 8D→4D Information Projection Framework Recovers Standard Lagrangian Dynamics, Derives the Cosmological Constant, and Resolves Open Pathologies of Quantum Field Theory (Version 1). Zenodo. https://doi.org/10.5281/zenodo.18905302
Macedonia, C. (2026). The 168 Monads: Walk-States on the Fano Plane, Frobenius Orbits, and the Standard Model Spectrum. Zenodo. https://doi.org/10.5281/zenodo.18905360
Macedonia, C. (2026). Computational Saturation Depth and the Fine-Structure Constant: A Fano–Pascal Incidence Structure. Zenodo. https://doi.org/10.5281/zenodo.19008659
Macedonia, C. R. (2025). The Primordial Algebra: The {-1, 0, 1} Generation and C-Closure Theorem. Preprints. https://doi.org/10.20944/preprints202512.1029.v1
Macedonia, C. (2026). Singularities of the Octonionic Projection: A Steiner–Feynman–Kac Construction on the Fano Fiber and the Weinberg Angle (Version 2). Zenodo. https://doi.org/10.5281/zenodo.18728094
Macedonia, C. (2026). A Purely Mathematical Derivation of the Fine-Structure Constant Within 1.62σ of CODATA 2022. Preprints. https://doi.org/10.20944/preprints202508.1294.v3
Macedonia, C. R. (2025). On the Extension of Peano’s Axioms to Total Functions: Triadic Information Dynamics and Geometric Invariants Within Specialized Physical Systems. Preprints. https://doi.org/10.20944/preprints202510.0870.v1
Macedonia, C. (2025). A Geometric Derivation of the Weinberg Angle from Discrete Octonionic Operators. Preprints. https://doi.org/10.20944/preprints202511.0690.v1
Macedonia, C. (2025). The Kosmoplex Primer: A Treatise on the Axiomatic Foundations of Theoretical Engineering. Preprints. https://doi.org/10.20944/preprints202508.0360.v2.v1
Macedonia, C. (2025). The Constructable Elements of Kosmoplex Theory A Supplement to the Kosmoplex Primer Including Axioms, Theorems, Proofs and Definitions (Version 1). Zenodo. https://doi.org/10.5281/zenodo.1706995119
Macedonia, C. (2025). A Condensed and Simplified Explanation of Kosmoplex Theory (Version 1). Zenodo. https://doi.org/10.5281/zenodo.17101719
GitHub: github.com/KosmoNexus — open-source simulation code and repositories
Replit — Fano Walks: https://fano-walks-christianmaced4.replit.app/ — interactive Fano plane walk calculator
Replit — K-Set Globe:https://k-set-globe-kosmonexus.replit.app — 8D→4D projection visualizer
Replit — Pascal Fano Explorer:
Replit -- Lagrangian Bridge: https://lagrangian-bridge.replit.app
We derive α⁻¹ = 137.035999143 from seven axioms — the five Peano axioms plus Triadic Closure and Computability — with zero free parameters. Hurwitz's theorem forces the octonions as the unique substrate. The Fano plane organizes 42 computational primitives. The projection from 8D to 4D operates through a channel whose capacity is 2×C(8,4) − 3 = 137, refined by four geometric corrections — each a named mathematical constant with a specific physical role.
Agreement with CODATA 2022: 1.62σ. No post-hoc adjustment is possible because there are no free parameters.
.Description: In this video, Dr. C. Macedonia introduces the Kosmoplex Sphere Model—an interactive 8D computational framework supporting his IEEE Computer article. Built on 7 axioms and 42 mathematical "glyphs", Kosmoplex explores how reality may compute itself, projecting from 8D into the four of space-time. You’ll learn:
• What Kosmoplex Theory proposes
• How the triadic structure (−1, 0, +1) generates 42 glyphs
• How computation, memory, and projection are visualized in the rotating S7 Sphere
QM and KT, Together: A Handout
This PDF is a list of the 10 biggest points of contention in Quantum Mechanics and how Kosmoplex Theory seamlessly addresses these and enhances QM.